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KMID : 1149220130210010119
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Korean Journal of Oriental Medical Prescription
2013 Volume.21 No. 1 p.119 ~ p.130
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Therapeutic Effect of Doinseunggi-tang on Diabetic Vascular Dysfunction
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Lee Yun-Jung
Kim Eon-Kuk
Kim Hye-Yoom
Yoon Jung-Joo
Lee So-Min
Lee Geon-Mok
Kang Dae-Gill
Lee Ho-Sub
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Abstract
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Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes.
Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks.
Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta.
Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis
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KEYWORD
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Doinseunggi-tang, Hypertension, Diabetes, Vasorelaxation, Cholesterol.
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